学术LDLc遗传倾向升高或增加主动

（英文原文）AssociationofLDL-cRelatedGeneticVariants

StudyQuestion:

Isthereanassociationbetweenlow-densitylipoproteincholesterol(LDL-c),high-densitylipoproteincholesterol(HDL-C),ortriglycerides(TGs)andaorticvalvedisease?

Methods:

Weightedgeneticriskscores(GRSs,ameasureofthegeneticpredispositiontoelevationsinplasmalipids)wereconstructedusingsingle-nucleotidepolymorphismsidentifiedingenome-wideassociationstudiesforplasmalipids.UsingaMendelianrandomizationstudydesign,GRSsthenwereevaluatedforanassociationwithaorticvalvedisease.Thepopulationincluded







































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