TODAY今日发布CircCardiovascIntervAug01,:13(8)今日发布01篇EBioMedicineEarlyRecent,July29,今日发布01篇CATHETERCARDIOINTEEarlyRecent,July29,今日发布01篇ClinicalandTranslationalScienceEarlyRecent,July29,今日发布01篇ClinicalCardiologyEarlyRecent,July28,今日发布01篇ClinicalTransplantationEarlyRecent,July28,今日发布01篇JournalofCachexia,SarcopeniaandMuscleEarlyRecent,July29,今日发布02篇JournalofCardiacSurgeryAug01,:35(8),-今日发布76篇ResearchandPracticeinThrombosisandHaemostasisEarlyRecent,July29,今日发布01篇RECOMMEND推荐阅读01miR-降低人和小鼠脂肪组织胰岛素受体表达，促进全身胰岛素抵抗EBioMedicineArticleBiagioArcidiacono,EusebioChiefari,etc.1小时前等22用户推荐阅读本文BackgroundInsulinresistanceinvisceraladiposetissue(VAT),skeletalmuscleandliverisaprominentfeatureofmostpatientswithobesity.Howthisassociationarisesremainspoorlyunderstood.Theobjectiveofthisstudywastodemonstratethatthedecreaseininsulinreceptor(INSR)expressionandinsulinsignalinginVATfromobeseindividualsisanearlymolecularmanifestationthatmightplayacrucialroleinthecascadeofeventsleadingtosystemicinsulinresistance.内脏脂肪组织（VAT）、骨骼肌和肝脏中的胰岛素抵抗是大多数肥胖患者的显著特征。这种联系是如何产生的仍不清楚。本研究的目的是证明肥胖个体的胰岛素受体（INSR）表达和胰岛素信号转导的降低是早期的分子表现，可能在导致系统性胰岛素抵抗的级联事件中起关键作用。扫描
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